我们将继续利用研究成果来开发新的护理疗程，最近推出的Pro-Youth Lifting Method by Natura Bissé就是一个很好的例子，疗程中包含引导式呼吸法、迷走神经刺激法以及独有的放松和提拉动作。该护理旨在短时间内提升整体健康水平和幸福感。当然，我们还在努力将其优势扩展到其他专业领域。
Exclusive Interview with Mr. Zhao Jingdong, Co-founder of Guangzhou FICOSOS Technology Co., Ltd. (FICOSOS Origin)
The onset of aging is essentially the aging of cells. When it comes to “rejuvenating” cells, replenishing nutrients, boosting vitality, and achieving anti-aging goals, a key factor is the FICOSOS Extracellular Vesicles technology that has entered the public eye in recent years. This technology, which supplements more than 500 protein-related factors, nourishes and repairs skin cells, allowing cells to “rejuvenate” and arguably exhibit “reverse aging” effects.
The product based on FICOSOS Extracellular Vesicles technology is called FICOSOS Cell Revitalizing Essence, which originates from cell laboratory technology and has been developed as a cell-free therapy. Its core technology, similar to the regenerative iterative therapy popular among celebrities in Dubai, Europe, and the United States, is a cell-free therapy and falls under the application category of mesenchymal stem cell-derived extracellular vesicle technology in the field of regeneration.
“This technology utilizes top international 3D suspension culture technology, selecting high-activity, stable, safe, and effective extracellular vesicle technology components to achieve superior cell regeneration effects,” said Mr. Zhao Jingdong, co-founder of Guangzhou FICOSOS Technology Co., Ltd., in an interview with SpaChina.
The term “Extracellular Vesicle Technology” may be unfamiliar to our readers. Please explain it to us in detail.
American top influencer and 42-year-old entertainment icon Kim Kardashian shared her beauty secret to maintain eternal youth on her social media last year, mentioning “extracellular vesicle technology.”
She revealed on her social media that she prefers a combination of laser therapy and extracellular vesicle technology for facial treatments. She also posted a video showing herself undergoing laser treatment by Dr. Ashkan Ghavami, a plastic surgeon in Beverly Hills. In the video, she explained that the primary purpose of the laser was to remove sun damage and sunspots, with the focus being on the subsequent use of “extracellular vesicle technology” to further restore the normal function of skin cells, reversing the signs of aging. The video showed her face and neck covered with a layer of extracellular vesicle technology product after the laser procedure.
In June 2023, research teams from Campbell University and others published a review report titled “The Potential Role of Exosomes in Aesthetic Plastic Surgery: A Review of Current Literature” in the professional journal Plast Reconstr Surg Glob Open (Plastic Surgery). The study report indicated that the continuous desire to combat aging has driven the demand and rapid popularization of non-surgical cosmetic methods. Over the past decade, extracellular vesicle technology, as a local, subcutaneously deliverable solution, has received particular attention because it has been confirmed to have regenerative properties as well as potential positive effects on wound healing, scar modification, and hair growth.
In the section on the application of cosmetic surgery, the research report stated that skin aging is a complex mechanism involving both internal and external processes, clinically manifested by decreased thickness of the epidermis and dermis, deepening wrinkles, pigmentation, enlarged pores, and weakened soft tissue elasticity. Although skin aging is caused by multiple factors, a key factor is cellular aging, such as keratinocytes, fibroblasts, and melanocytes.
Therefore, the mechanism of extracellular vesicle technology, which stimulates the proliferation and migration of fibroblasts, has attracted the interest of research teams. In vitro and in vivo studies of UV-B photoaging models have shown that extracellular vesicle technology can protect cells from UV-B damage by reducing inflammatory markers such as tumor necrosis factor-α (TNF-α) and upregulating transforming growth factor-β(TGF-β) and tissue inhibitors of metalloproteinases. These mechanisms further lead to the reversal of fibroblast aging, upregulation of collagen I, elastin, and fibronectin production, and reduction of collagen III expression.
Moreover, studies evaluating the combination of local extracellular vesicles with non-surgical facial treatments have shown synergistic effects. The research report indicated that compared to using microneedles alone, the combination of local extracellular vesicles and facial microneedles can produce better skin quality, texture, tone, vascular distribution, clarity, and overall satisfaction among patients. Therefore, extracellular vesicle technology has gradually entered the medical aesthetics industry in recent years, and an increasing number of clinical success stories have captivated users and delighted doctors.
Can you describe how extracellular vesicles improve hair loss?
It is well known that hair growth is closely related to the health of hair follicles. Hair follicles are complex tiny organs, and at different stages of the hair follicle growth cycle, dermal papilla (DP) cells located at the base of the hair follicle send signals to keep the hair follicle dormant or initiate growth. However, for the most common type of hair loss, androgenetic alopecia in men, the function of DP cells is abnormal, meaning that dormant hair follicles do not receive signals for extended periods.
In fact, in areas where baldness occurs on the scalp, hair follicles do not disappear but shrink, a process referred to as “follicular miniaturization,” such as the features seen in male pattern baldness where hair follicles shrink at the crown, resulting in thinning hair and eventual diffuse thinning. Therefore, if the vitality of DP cells in these areas can be restored, dormant hair follicles may regain vitality and resume growth. Furthermore, extracellular vesicle technology also plays an important role in restoring the healthy “soil” environment of the scalp, so compared to other therapies, its effects can be sustained for a longer period.
Extracellular vesicle technology is a type of extracellular vesicle rich in various bioactive substances with therapeutic potential. Research has shown that extracellular vesicle technology has demonstrated remarkable potential in the treatment of skin diseases such as hair regeneration, oxidative stress, wound healing, and specific dermatitis and has entered clinical trials in these areas.
A research team from the Department of Molecular Biomedical Sciences and the Institute of Comparative Medicine at North Carolina State University published a study entitled “Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling” in Science Advances, demonstrating that the key to hair regeneration lies in the miRNA of vesicles, which can activate DP cells by regulating the β-catenin signaling pathway, thereby promoting hair regeneration.
Because extracellular vesicle technology projects have many advantages such as non-drug dependence, high biocompatibility, and minimal side effects, they are expected to become a new and effective treatment for hair loss in the foeseeable future.
So can women also improve the condition of scalp cells through extracellular vesicles?
Certainly. Currently, with the global economic downturn and increasing social competition pressure, hair loss is on the rise for both men and women. Therefore, Ocellus, the representative of regenerative medicine with extracellular vesicle technology as the core, offers Ocellus Hair Follicle Cell/Hair Regeneration Comprehensive Solution, which can repair and regenerate cells at the cellular level for both men and women, achieving the goal of scalp anti-aging.
We can see from various data that there is a trend of younger hair loss population globally, and even women are not spared. Among those affected by hair loss, the proportion of women has reached 35%, indicating that hair loss is no longer just a concern for men. Hair loss has a greater impact on women’s appearance, so it is necessary to understand the reasons for severe hair loss and prepare in advance. From my perspective, the reasons include, but are not limited to:
Excessive dieting: If dieting is not accompanied by balanced nutrition, it can lead to nutrient deficiencies in the body, resulting in hair loss.
Menopause: The decline in physical function during menopause accelerates, and at the same time, metabolic capacity also declines rapidly, resulting in hormonal imbalances and many cases of severe hair loss.
Frequent hair dyeing and perming: Both hair dyes and perms contain chemical ingredients. When these ingredients come into contact with the scalp, they directly damage hair follicle cells, leading to hair loss.
Stress: The “involution” of modern society is particularly severe, with competition everywhere. Long-term exposure to environments with high mental stress and tension can result in a large amount of hair loss for both men and women.
Staying up late: Long-term staying up late affects the body’s biological clock, leading to hormone and endocrine disorders, and hair loss follows suit.
Pregnancy and postpartum: Pregnancy and postpartum periods are high-risk periods for female hair loss because hormone levels in the body undergo drastic changes, especially a significant increase in estrogen levels, which can shorten the hair growth cycle, lengthen the dormant period, and increase the probability of hair loss.
Past methods for preventing hair loss and promoting hair growth often have various limitations, poor user experience, long recovery periods, slow efficacy, and significant side effects, so the “head-top major event” of hair loss has not been well resolved even in modern times. Both hair loss sufferers and the hair loss prevention and treatment industry urgently need a breakthrough solution.
The Hair Follicle Cell/Hair Regeneration Comprehensive Solution starts from the root cause of hair loss, innovates the treatment principle, focuses on scalp whole-cell “regeneration” as the core, and simultaneously addresses the problems of hair loss regeneration, hair retention and prevention, sparse softening and thickening, and scalp environment improvement, tackling both the symptoms and the root causes. It truly innovates in terms of efficacy, treatment methods, and user experience, breaking through the limitations of all current therapies and guiding the mainstream trend of future hair loss prevention and treatment.
Is FICOSOS extracellular vesicle technology safe?
Yes, it is safe. Because the effective ingredients of Ocellus “extracellular vesicle technology” are humanized, there is no risk of rejection, and the safety factor is extremely high. Only clinical treatments with mid-germ layer techniques are needed, using minimally invasive and non-invasive techniques such as rolling needles and nano-crystals for the implementation of cell-free therapy projects.
For the skin, this therapy has key effects of “three anti and three improvements”: anti-inflammatory, anti-glycation, anti-oxidant, cell improvement, blood vessel improvement, and collagen improvement. It can alleviate symptoms such as fine lines, spots, sensitivity, dullness, and enlarged pores, making the skin appear rejuvenated. For the scalp, once the scalp skin and hair follicles are regenerated, they can simultaneously promote hair growth, retain hair, improve hair quality, and scalp environment. For private areas, it can efficiently repair the health and moisture of mucous membranes and has anti-inflammatory and antibacterial effects. These principles are the same.
How does FICOSOS Extracellular Vesicle technology cooperate with medical spas with qualifications? What kind of treatment plans can be recommended?
For medical aesthetic spas, FICOSOS projects have stable customer retention, customer growth, and high repurchase rates, and they are also perennial projects with high investment returns and long profit lifecycles. If these institutions need to develop or upgrade regenerative medical projects in the high-end anti-aging field, such as skin anti-aging, private customization, hair follicle regeneration (hair loss), and eye age management, FICOSOS provides product + technical solutions and collaborates with professional teams to customize project development plans and empower projects throughout the entire cycle, including training.
In addition, we value the mutual growth along with customers. Based on the current cooperation with customers, generally after six months of cooperation, the overall quality and capabilities of the institution’s team can be doubled. This can be seen from three key dimensions: professional promotion, sales force, and customer satisfaction.
In terms of project treatment plans, considering the blue ocean market, growth rate, and average customer spending, it is recommended to first promote hair follicle regeneration and private customization; eye age management can be upgraded differentially. The purpose of the project is to “solve problems for customers and provide a higher quality of life,” so it should be divided according to different needs and stages. For example, in the treatment phase, the goal is to solve the problem, so it is recommended to have 3-6 sessions, at least once a month. After that, it is the continuous maintenance phase, with the aim of maintaining the status quo, with a recommended frequency of once every 3 to 6 months, completing the customer’s treatment to follow-up management. In terms of service process and package design, taking hair follicle regeneration as an example, it is recommended to start with scientific testing, using the American hair detection instrument D200, followed by FICOSOS regenerative medicine, and then follow-up with existing maintenance projects in the store, designing a full three-step set. In combination with our market operation experience and customer management experience, there are usually different personalized adjustments.
2023年6月，美国坎贝尔大学等研究团队在行业专业期刊Plast Reconstr Surg Glob Open(整形外科学术)上发表了题为The Potential Role of Exosomes in Aesthetic Plastic Surgery: A Review of Current Literature(外泌体在美容整形手术中的潜在作用)的综述报告。该研究报告表明，对抗衰老的持续渴望推动了非手术美容方式的需求与快速普及。在过去的十年当中，细胞外囊泡科技作为一种局部、可皮下给产品的解决方案，尤其受到了关注，因为证实其具有再生特性以及对伤口愈合、疤痕修饰，以及毛发生长的潜在作用。
Interview with Mr. Alexandre Vacher, the CEO of Laboratoire Sintyl
Since 1974, Laboratoire Sintyl, headquartered in Geneva, Switzerland, has been synonymous with innovation, pioneering research, testing and production, and excellent quality and safety. Physiocoiffeur is a targeted and innovative system that combines specific working techniques with a complete range of the highest-quality products. Physiocoiffeur is a critical concept for those determined to improve their scalp and hair conditions and to eradicate not only the symptoms but also their fundamental causes.
At the root of every problem, there is always an imbalance, which is where Physiocoiffeur goes into action. The plant ingredients, essential oils, and massages make the treatments as pleasant and engaging for those who receive them as they are for those who give them. The health and treatment of one’s hair can become a genuine ritual for wellbeing. The Physiocoiffeur concept is rooted in the receiver’s awareness and is characterized by the specific nature of each treatment to achieve optimum results.
SpaChina interviewed Mr Alexandre Vacher, the CEO of Laboratoire Sintyl, to learn more about Physiocoiffeur’s evolution intensive product and concept.
Could you please introduce to our SpaChina readers the concept of PHYSIOCOIFFEUR®, and what makes it successful?
PHYSIOCOIFFEUR® is a highly professional and skilled method that allows haircare professionals to treat every client according to their own special needs and problems while also allowing clients to “follow up” at home using maintenance products. The aim of this method is as simple as it is pioneering: treat all scalp concerns to restore the scalp’s natural balance.
The success of PHYSIOCOIFFEUR® is based on a few key concepts below:
Optimum-quality: Our products are designed and tested by our team of researchers and produced using plants, essential oils, and natural extracts.
Synergy between the products and massages: By matching two or more products, a customised blend with increased precision can be obtained. The products, when combined with massage techniques, increase the effectiveness of the treatments.
Client analysis: Studying the client as a unique individual is rewarding but also essential for understanding the person to be treated. It leads to an analysis not only of the imperfections and problems related to the skin but, more generally, of the physical and psychological imbalances that may be present. Drawing up the “analysis sheet” establishes a personal relationship, which is useful for getting to know the dynamics causing the physiological discomfort. Identifying an individual’s morphology generates an awareness, starting with the somatic features, of specific dysfunctions, defects, or blemishes.
Could you explain more about how the Micro-encapsulated Plant Stem-Cell extracts promote natural hair growth and fight the signs of hair aging?
Plant Stem-cell extracts: Every stem cell contains specific epigenetic factors whose task is to preserve the stem cells’ multi-potency and its ability to self-renew. Laboratoire Sintyl researchers encapsulated the plant stem cells, derived from a rare Swiss apple variety and other plants, selected for their efficacy on hair growth. These stem cells are rich in epigenetic factors and metabolites, which ensures the longevity of skin cells while also delaying the senescence of hair follicles.
This is an innovative treatment that meets the specific needs of the scalp and hair to fight against hair loss and promote natural hair growth. A scientifically-proven formula that fights all the signs of capillary aging, intensifies and strengthens the hair. It is very famous for its excellent storability without shriveling. Applied in the right way, they have a positive impact on the vitality of skin stem cells and their proper functioning, to promote natural hair growth.
What makes this product special and unique?
We can share its uniqueness from these 4 angles:
Efficient formula: scientifically proven formula with high concentrations of different kinds of Swiss stem cells, microencapsulated in order to boost their efficacy.
Technology: Micro-encapsulation of high concentrated stem-cells to take the best advantage of stem-cells in boosting natural hair growth.
Visible results: +58% more growth of hair shafts VS control after 14 days of use, in vitro study on cultured hair follicles.
Method of use: This intensive hair boosting program consists of one Capillary serum booster and 7 Capillary revitalizing fortifying fluid. By mixing the 2 liquids using a syringe extractor, clients would have a pleasant DIY experience.
Product benefits including prevention of hair-loss, acts on all sign of hair aging, strengthens the hair, stimulates natural hair growth, and a protective anti-free-radical action to prevent the oxidation of natural hair pigments, with preserves the natural brightness of the hair.
What are the latest trends you see for hair and scalp care worldwide? Do people care for their hair and scalp more than before? Does the market now have more players?
Indeed, the attention to hair and scalp care has intensified, with more individuals seeking solutions that offer both aesthetic benefits and health improvements. Physiocoiffeur’s approach – grounded in the synergy of advanced trichology, personalized care, and natural ingredients – places us at the forefront of this shift. As the market grows and evolves, we continue to innovate, ensuring that our products and treatments meet the changing needs of our clients, reinforcing our commitment to their hair’s health and beauty. Here are the 4 trends I have observed:
Holistic scalp health: At Physiocoiffeur, we’ve always championed the philosophy that beautiful hair starts with a healthy scalp. This aligns with the global trend towards a more holistic approach to hair care, where the scalp’s well-being is paramount. Our innovative products and treatments are specifically designed to nurture the scalp, restoring its balance and addressing issues like sensitivity, dryness, and excess oil production. This focus on scalp health as the foundation of hair beauty is something our customers increasingly appreciate and seek out.
Emphasis on natural ingredients: In response to the worldwide shift towards natural and sustainable products, Physiocoiffeur has been at the forefront, utilizing high-quality, natural ingredients that are kind to both hair and environment. Our commitment to producing dermatologically tested, Swiss-manufactured treatments underscores our dedication to safety, efficacy, and sustainability—a commitment that resonates with today’s eco-conscious consumers.
Customized hair and scalp care: Understanding the unique nature of each individual’s hair and scalp needs, Physiocoiffeur offers personalized treatments and products. Our expertise in trichology – the study of hair and scalp health – enables us to create customized solutions that address specific concerns, whether it’s managing dandruff, restoring thinning hair, or revitalizing dull, lifeless locks. This bespoke approach has become a cornerstone of our brand, distinguishing us in a market that increasingly values personalization.
Advancements in home care: With the recent shift towards at-home beauty routines, Physiocoiffeur has expanded our range to include products that allow consumers to enjoy professional-grade hair and scalp care in the comfort of their homes. From our scalp serums to our rejuvenating shampoos and conditioners, we provide everything needed to maintain salon-quality results between visits.
The entry of new brands and the expansion of existing ones into the hair and scalp care market reflect the growing importance of this segment. Physiocoiffeur, with our rich history since 1974 and our continuous innovation in product development and treatment techniques, remains a leading and trusted name amid this expansion. Our dedication to quality, innovation, and customer satisfaction ensures that we not only keep pace with market trends but often set them, offering our clients and partners unparalleled hair and scalp care solutions.
How do you define Physiocoiffeur’s users?
Physiocoiffeur’s users are diverse, yet they share a common desire for hair and scalp care products that are safe, effective, and grounded in scientific research. They appreciate the luxurious experience our products provide, backed by the assurance of Swiss quality and innovation.
At the beginning we were the mostly chosen by have clients who were struggling with their scalp condition and were deeply affected by dandruff, oily scalp, hair-loss, etc, desperate to find a solution to naturally improve their condition. Nowadays, our customer base has expanded, with younger customers and beauty enthusiasts, who are passionate about beauty and wellness trends and are always on the lookout for high-quality, innovative products.
Usually Spas in China (both hotel spas and day spas) lack knowledge of hair and scalp treatment. What is your advice for them to step into the treatment of hair and scalp?
By partnering with Physiocoiffeur, spas in China can confidently step into the realm of hair and scalp care, offering their clients an expanded portfolio of wellness treatments. Our commitment to quality, innovation, and education ensures that spas are well-equipped to meet the growing demand for holistic hair and scalp wellness solutions, setting them apart in the wellness industry.
Recommended starter protocol: Scalp Analysis and Treatment Protocols: Begin with our scalp analysis methodology. A proper diagnostic is fundamental.
Scalp peeling: our gentle, detoxifying peeling treatment is designed to remove impurities, cleanse the scalp of excess sebum and dandruff, and restore the physiological balance of the scalp.
Scalp shampoos: meticulously formulated with natural active ingredients to address various scalp conditions, they offer personalized cleansing solutions that promote the health and balance of the scalp.
Scalp lotions: Maintaining the scalp’s pH balance is crucial for protecting the skin, ensuring the scalp’s barrier function remains intact, and keeping hair healthy, shiny, and strong.
Scalp serums: Tailored essential oil blends for different scalp conditions, perfect for a luxurious, sensory treatment experience.
Our team of professionals are able to provide advanced training and help you become a scalp specialist, allowing you to expand your spa services and reinforce customer loyalty.
What’s your business coverage now worldwide?
Outside of Switzerland, Physiocoiffeur is present in salons, clinics and spas of 12 countries worldwide. We are extremely selective with distributors and point of sales willing to cooperate, in order to ensure they embrace the brand’s value.
We are also looking forward to expanding more in China. Having lived myself in China, this wonderful country will always have a special place in my heart. Our approach to working with our China team is centered on collaboration, communication, and cultural understanding. I am personally committed to contribute to the brand’s development in China, as it is part of our strategy.
